Endocrine Abstracts

In mammals, spontaneous apoptosis is observed particularly in differentiating spermatogonia and spermatocytes. We have previously demonstrated that 17β-estradiol (E2) in primary rat pachytene spermatocytes (PS) binds ESR1 and GPER1 to activate EGFR/ERK/c-Jun pathway leading to up regulation of bax, a pro-apoptotic factor. Aim of this study was to clarify the effector pathway(s) controlling spermatocytes apoptosis using as model GC-2 cells, an immortalized mouse...